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KMID : 0941820180280040273
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Korean Journal of Clinical Pharmacy
2018 Volume.28 No. 4 p.273 ~ p.278
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Bile Acids and the Metabolic Disorder
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Roh Ji-Hye
Yoon Jeong-Hyun
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Abstract
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Bile acids are major constituents of bile and known to help absorb dietary fat and fat-soluble vitamins in the gastrointestinal tract. In the past few decades, many studies have shown that bile acids not only play a role in fat digestion but also function as broadrange of signal transduction hormones by binding to various receptors present in cell membranes or nuclei. Bile acid receptors aredistributed in a wide range of organs and tissues in the human body. They perform multitudes of physiological functions withcomplex mechanisms. When bile acids bind to their receptors, they regulate fat and glucose metabolism in a tissue-specific way. In addition, bile acids are shown to inhibit inflammation and fibrosis in the liver. Considering the roles of bile acids as metabolicregulators, bile acids and their receptors can be very attractive targets in treating metabolic disorders. In the future, if roles of bileacids and their receptors are further clarified, they will be the novel target of drugs in the treatment of various metabolic diseases.
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KEYWORD
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Bile acid, metabolic disorder, receptor, metabolism
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